Possible food and drug interactions when taking Aciphex

Consumer Information (PDR)

If AcipHex is taken with certain other drugs, the effects of either could be increase, decreased, or altered. It is especially important to check with your doctor before combining AcipHex with the following:

Cyclosporine (Neoral, Sandimmune)
Digoxin (Lanoxin)
Ketoconazole (Nizoral)
Warfarin (Coumadin)

Consumer Information (Cerner Multum)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rabeprazole, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to rabeprazole. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Studies have not been done in humans. However, studies in animals have not been shown that rabeprazole causes harm to the fetus.

Breast-feeding—Rabeprazole may pass into the breast milk. Since this medicine has been shown to cause a decrease in body weight gain in animal studies, it may be necessary for you to take another medicine or to stop breast-feeding during treatment. Be sure you discussed the risks and benefits of the medicine with your doctor.

Children—There is no specific information comparing the use of rabeprazole in children with use in other age groups.

Older adults—In studies done to date that have included older adults, rabeprazole did not cause different side effects or problems than it did in younger adults.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking rabeprazole, it is especially important that your health care professional know if you are taking any of the following:

• Cyclosporine (e.g., Neoral)—Rabeprazole may increase the amount of cyclosporine in the blood.

• Digoxin (e.g., Lanoxin)—Rabeprazole may increase the amount of digoxin in the blood.

• Ketoconazole (e.g., Nizoral tablets)—Rabeprazole may decrease the amount of ketoconazole absorbed into the body.

• Warfarin (e.g., Coumadin)—May cause serious unwanted effects including abnormal bleeding

Other medical problems—

• Liver disease—May increase chance of side effects
• Stomach infection—May make the condition worse